Phcog Mag [serial online] 2013 [cited 2019 Sep 6];0-6. 2013/9/36/350/117832Hemorrhoid complaints are one of the most common afflictions.
The problem can occur at any age and can affect both sexes.
This resin is an astringent antiseptic with anti-inflammatory and demulcent properties.
Avicenna, the famous physician of Persian medicine, believes that Commiphora Mukul (CM) is one of the best herbal monotherapy for hemorrhoids, which can be used orally or topically.
The nature of these compounds is shown in [Figure 1], and the scheme on segregation of CM is shown in [Figure 2].
The gum resin of Commiphora proved to be a rich source of steroids.It has been reported that 1 in 3 persons with symptomatic hemorrhoids seek medical help.Women have an increased prevalence during pregnancy and in the postpartum period.Angiogenesis is evident in hemorrhoid tissue, suggesting the possible mechanism in the pathogenesis of hemorrhoids.The direct degeneration effect of MMP9 (matrix metalloproteinase-9), on supporting structure elastic fibers in anal cushion, is another important mechanism.The use of laxatives including high-fiber diet, bulking agents, stimulants, fecal softeners, osmotic agents, show a consistent beneficial effect for relieving overall symptoms and bleeding in the treatment of symptomatic hemorrhoids.Drugs which improve microcirculation, capillary flow and vascular tone, and strengthen connective tissue of the perivascular amorphous substrate, can relieve capillary impairment and venous insufficiency. wightii, Indian bdellium) Burseraceae, which has exuded from the bark and dried in the air, is the pale yellow granular secretion that is discharged into cavities in the bark when it is wounded.Numerous theories concerning the pathogenesis of hemorrhoids have been proposed, but the exact mechanism remains elusive.Constipation and straining were once accepted as the major cause of hemorrhoidal disease, but this is considered to be a gross oversimplification.Forty-nine patients were assigned randomly to receive Land A and 50 to receive CM.After 4 weeks, flatulence, dyspepsia, GER, and colonoscopic grading scores significantly decreased in study group, whereas in control group constipation, painful defecation, and proctorrhagia showed better but not significant improvement.