Numerous epidemiological studies and randomized controlled trials have documented the association between elevated LDL-C levels with increased CVD risk in both diabetic and nondiabetic populations [8, 9].Thus reducing LDL-C levels is the primary goal of therapy for diabetic dyslipidemia [5, 10].
Essentially, T2DM lipid profiles consist of elevations in triglyceride (TG) levels (2 mmol/L) and reductions in high-density lipoprotein cholesterol (HDL-C).
While low-density lipoproteins cholesterol (LDL-C) concentration levels are normal, the particles are denser and smaller in size, which is believed to enhance their atherogenic potential [7].
Atorvastatin reduced LDL-C the most at a dose of 40 mg (22.8%), and pravastatin reduced LDL-C the most at a dose of 20 mg (20.3%).
All three statins were safe in relation to muscular and hepatic functions.
The matrix effects of plasma were in the range of 102.7–105.5% for atorvastatin and 90.3–96.6% for atorvastatin lactone.
This method was successfully applied in clinical studies of atorvastatin in coronary artery disease patients.
More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-Co A) Reductase, which catalyzes the conversion of HMG-Co A to mevalonic acid.
This is the third step in a sequence of metabolic reactions involved in the production of several compounds involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very low-density lipoprotein (VLDL).
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Comments Atorvastatin Thesis
A clinician's guide to statin drug-drug interactions - Journal of.
P-gp largely with lovastatin, simvastatin, and atorvastatin.9. passive absorption of atorvastatin acid. thesis necessary for hepatitis C replication. One study.…
Effects of Statins on Renal Function - Mayo Clinic Proceedings
Glomerular filtration rate;. GREACE = GREek Atorvastatin and Coronary–heart-disease Evaluation;. thesis, but inhibition of this enzyme also leads to down-.…
The total synthesis of calcium atorvastatin - Organic & Biomolecular.
A practical and convergent asymmetric route to calcium atorvastatin 1 is reported. The synthesis of calcium atorvastatin 1 was performed using the remote 1.…
Coadministration of Atorvastatin and Amiodarone Increases the Risk.
Nov 6, 2015. Keywords AmiodaroneAtorvastatinPulmonary fibrosis. in Human Lung Cells; Master of Science thesis, 2009 accessed January 23, 2015.…
The effects of statins on mitochondrial function
Days of in vivo administration of simvastatin or atorvastatin reduces mitochondrial respiratory. with either 40-mg simvastatin or 80-mg atorvastatin, administered orally. The effects of statins on mitochondrial function Master's Thesis, East.…
Comparison of Efficacy and Safety of Rosuvastatin, Atorvastatin and.
Jan 3, 2013. Atorvastatin reduced LDL-C the most at a dose of 40 mg 22.8%, and. Scott to Ms. L. Barakat, as a supervisor of the M. S. degree thesis.…
A fixed dose triple combination therapy of acetylsalicylic acid.
Aspirin 100 mg + atorvastatin 20 or 40 mg + ramipril 2.5, 5 or 10 mg as a. Thesis. Sydney University of Sydney; 2014. 16. Bhatt DL, Eagle KA, Ohman EM.…
Statin Toxicity - AHA Journals
Jan 18, 2019. for simvastatin, lovastatin, and atorvastatin, whereas fluvas-. thesis and related to downstream proteins of the mevalonate pathway were.…
Efficacy of atorvastatin when not administered daily - SciELO
After a 12-week diet period, atorvastatin was initiated at a dose of 10 mg per day. This article is part of the thesis of master submitted by Antonio Edmond.…